Condition: Tinnitus · Epilepsy, Temporal Lobe · Sponsor: Assistance Publique - Hôpitaux de Paris
the investigators have recently shown that patients with drug-resistant temporal lobe epilepsy who have undergone brain surgery targeting the medial temporal lobe structures were more likely to develop tinnitus postoperatively. This discovery of a vulnerability to tinnitus associated with medial temporal lobe surgery to eliminate drug-refractory epileptic seizures provides a new clinical model of tinnitus, targeting temporal lobe regions as generators or mediators of this hearing disorder. The objective of this project is to study the impact of tinnitus on the cognitive, emotional, psychoacoustic and cerebral functioning associated with this hearing disorder, and to clarify the pathophysiology of tinnitus by comparing different groups of individuals with tinnitus (surgical epileptic patients or non-surgical ORL patients) to matched tinnitus-free groups (surgical tinnitus-free cases and healthy controls volunteer).
This description comes directly from the study's public registry record.
Sophie DUPONT, MD, Ph.D · 01 42 16 03 01 · sophie.dupont@aphp.fr
Séverine Samson, Ph.D · 03 20 41 64 43 · severine.samson@univ-lille.fr
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| Service de Soins de Suite et Réadaptation (SSR) Neurologique, DMU de Neurosciences | Paris, France | Recruiting |
| Hôpital Européen Georges Pompidou | Paris, France | Recruiting |
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Source record: clinicaltrials.gov/study/NCT04717388