Condition: Acute Hypoxemic Respiratory Failure · Sponsor: Hospital Universitari Vall d'Hebron Research Institute
Late or delayed intubation in patients with acute hypoxemic respiratory failure (AHRF) treated with nasal high flow (NHF) is associated with increased patient mortality. The ROX index has been designed and validated to predict outcome of NFH therapy by identifying those patients with a high risk of NHF failure and those with a high probability of success. Whether or not the ROX index may improve patient outcome remains to be shown. To do so, a strategy using the ROX index must lead to earlier intubation than commonly-used criteria. The objective of the ROX-1 trial is to assess whether the use of an algorithm incorporating the ROX index to standard of care for the time to intubation in patients with AHRF supported with NHF isassociated with an increase in the proportion of patients who are intubated within the first 12 hours among those patients who fail on NHF.
This description comes directly from the study's public registry record.
Oriol Roca, MD PhD · +34932746209 · oroca@tauli.cat
Always discuss trial participation with your own doctor first.
| Rush University Chicago Hospital | Chicago, Illinois, United States | Recruiting |
| First Affiliated Hospital of Chongqing Medical University | Chongqing, China | Not Yet Recruiting |
| The Second Military Medical University Hospital | Shanghai, China | Recruiting |
| Zhongshan Hospital, Fudan University | Shanghai, China | Not Yet Recruiting |
| Hospital Universitari Vall d'Hebron | Barcelona, Spain | Recruiting |
| Hospital del Mar | Barcelona, Spain | Recruiting |
| Hospital de Ciudad Real | Ciudad Real, Spain | Recruiting |
| Hospital Civil Fray Antonio Alcalde | Guadalajara, Spain | Recruiting |
| Hospital Son Llàtzer | Palma de Mallorca, Spain | Recruiting |
| Hospital Parc Taulí | Sabadell, Spain | Recruiting |
| Hospital Moisès Broggi | Sant Joan Despí, Spain | Recruiting |
| Hospital Virgen de la Salud | Toledo, Spain | Recruiting |
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Source record: clinicaltrials.gov/study/NCT04707729