Condition: Rheumatoid Arthritis · Sponsor: University of Alabama at Birmingham
The 2021 ACR RA treatment guideline, based on widely acknowledged low to moderate quality evidence, recommends switching to a non-tumor necrosis factor (TNFi) biologic (choose among existing medications, currently, rituximab, abatacept, tocilizumab, or sarilumab) or a targeted synthetic DMARD arm (tsDMARD; choose among existing medications, currently, tofacitinib, baricitinib, upadacitinib) in patients with active RA despite the use of a TNFi-biologic. In practice, most patients receive another TNFi-biologic, i.e., a second TNFi-biologic first. This is not based on solid evidence, but on arbitrary algorithms often proposed by health insurance plans, and/or physician experience and habit (TNFis launched 22 yrs ago vs. the first tsDMARD 8 years ago vs. first non-TNF-biologic launched 17 years ago). This study will fill a critical knowledge gap by generating CER data for important PROs between these treatment options, switching to a non-TNFi biologic or a tsDMARD in patients with active RA despite the use of a TNFi-biologic.
This description comes directly from the study's public registry record.
Jasvinder Singh · 205-975-2405 · Jsingh@uabmc.edu
Jeff Foster, MPH · 205-996-6086 · pjfoster@uabmc.edu
Always discuss trial participation with your own doctor first.
| East Alabama Arthritis Center PC | Auburn, Alabama, United States | Recruiting |
| Bendcare, LLC | Birmingham, Alabama, United States | Recruiting |
| University of Alabama at Birmingham | Birmingham, Alabama, United States | Recruiting |
| SunValley Arthritis Center, Ltd | Peoria, Arizona, United States | Recruiting |
| University of Arizona | Tucson, Arizona, United States | Recruiting |
| Pacific Arthritis Care Center | Los Angeles, California, United States | Recruiting |
| University of California, Los Angeles | Los Angeles, California, United States | Recruiting |
| Arthritis Medical Center | Nipomo, California, United States | Recruiting |
| Turlock Arthritis & Osteoporosis Center, | Turlock, California, United States | Recruiting |
| Center for Rheumatology Research | Woodland Hills, California, United States | Recruiting |
| George Munoz MD, PC | Aventura, Florida, United States | Recruiting |
| American Arthritis and Rheumatology Associates LLC | Clearwater, Florida, United States | Recruiting |
+ 37 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT04692493