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Study identifier: NCT04688528 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Dose De-escalation and Sentinel LN Mapping Driven Radiotherapy of Contralateral Neck in Ipsilateral Node Positive HNSCC

Condition: Squamous Cell Carcinoma of Head and Neck  ·  Sponsor: Universitaire Ziekenhuizen KU Leuven

PhaseNA
Planned participants147
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The study involves head and neck squamous cell carcinomas (HNSCC) of the oral cavity, oropharynx, larynx or hypopharynx with positive nodes on only one side of the neck and no distant metastasis treated by primary (chemo)radiotherapy. The elective node irradiation on the contralateral side is not always mandatory and the dose may be too high. In this study, we evaluate two strategies: the impact of sentinel lymph node mapping to tailor the volumes to irradiate and the dose reduction.

This description comes directly from the study's public registry record.

Talk to the study team

Jean-François Daisne, MD, PhD  ·  +32-16-34-76-00  ·  jean-francois.daisne@uzleuven.be

Chris Bruyninckx, BA  ·  +32-16-34-76-00  ·  chris.bruyninckx@uzleuven.be

Always discuss trial participation with your own doctor first.

Locations (10)

ZOLGenk, Limburg, BelgiumRecruiting
Jessa ZiekenhuisHasselt, Limburg, BelgiumRecruiting
OLV AalstAalst, BelgiumRecruiting
UCL Saint-LucBrussels, BelgiumRecruiting
Institute Jules BordetBrussels, BelgiumRecruiting
University Hospital GentGhent, BelgiumRecruiting
Universitaire Ziekenhuizen LeuvenLeuven, BelgiumRecruiting
AZ Sint-MaartenMechelen, BelgiumRecruiting
CHU-UCL NamurNamur, BelgiumRecruiting
AZ TurnhoutTurnhout, BelgiumRecruiting

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Source record: clinicaltrials.gov/study/NCT04688528