Condition: NAFLD · Sponsor: University Hospital, Angers
NAFLD, closely linked to overweight and insulin resistance, has reached 25% prevalence worldwide. Advanced liver fibrosis(ALF) must be accurately diagnosed in NAFLD because it defines a subgroup of patients with impaired prognosis, and these patients need a specific management to prevent the occurrence of liver-related complication. Relatively few NAFLD patients develop ALF and it is a challenge for physicians to identify them. Liver biopsy is the reference for liver fibrosis evaluation but this invasive procedure cannot be first-line used in NAFLD. Non-invasive diagnosis of liver fibrosis is now available, especially liver stiffness measurement (LSM) with Fibroscan and blood fibrosis tests. However, Fibroscan is a costly device available only in few specialized centres with thus poor accessibility in face of the large NAFLD population. Blood fibrosis tests can be performed by every physician and are distinguished as "complex" or "simple". Because they include specialized biomarkers, complex blood fibrosis tests are accurate for the diagnosis of ALF but they are quite expensive and not reimbursed, with therefore limited use in clinical practice. Simple blood fibrosis tests have the advantage to include cheap and easy-to-obtain biomarkers with simple calculation thanks to free websites or smartphone applications. Simple blood fibrosis tests are globally less accurate than complex blood fibrosis tests or Fibroscan but, used with a high-sensitivity cut-off, they have the high i…
This description comes directly from the study's public registry record.
Jérôme Boursier, MD-PHD · +33241353410 · jeboursier@chu-angers.fr
Marc de Saint Loup · +33241357812 · madesaintloup@chu-angers.fr
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| University Hospital of Angers | Angers, France | Recruiting |
| University Hospital of Besançon | Besançon, France | Not Yet Recruiting |
| Avicenne Hospital (Greater Paris University Hospitals) | Bobigny, France | Not Yet Recruiting |
| University Hospital of Dijon | Dijon, France | Recruiting |
| Departemental Hospital Center of Vendée | La Roche-sur-Yon, France | Recruiting |
| University Hospital of Grenoble | La Tronche, France | Active Not Recruiting |
| University Hospital of Lille | Lille, France | Active Not Recruiting |
| University Hospital of Limoges | Limoges, France | Active Not Recruiting |
| Edouard Herriot Hospital | Lyon, France | Not Yet Recruiting |
| La Croix Rousse Hospital | Lyon, France | Recruiting |
| Saint Joseph Hospital | Marseille, France | Not Yet Recruiting |
| University Hospital of Montpellier | Montpellier, France | Recruiting |
+ 8 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT04681573