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Study identifier: NCT04678648 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Trial of RSC-1255 for Treatment of Patients With Advanced Malignancies

Condition: Advanced Malignant Solid Neoplasm · RAS Mutation · Lung Cancer  ·  Sponsor: RasCal Therapeutics, Inc.

PhasePhase 1
Planned participants134
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

RSC-101 is a Phase 1a/1b clinical trial of RSC-1255 in adult study participants with advanced solid tumor malignancies who are intolerant of existing therapies known to provide clinical benefit, have disease that has progressed after standard therapy, or have previously failed other therapies. The study has two phases. The purpose of Phase 1a (Dose Escalation) is to confirm the appropriate treatment dose and Phase 1b (Dose Expansion) is to characterize the safety and efficacy of RSC-1255.

This description comes directly from the study's public registry record.

Talk to the study team

Michael Mann, MD  ·  310-498-7171  ·  clinicaltrials@rascaltherapeutics.com

Always discuss trial participation with your own doctor first.

Locations (3)

University of California, Los Angeles (UCLA) Department of Medicine - Hematology/OncologyLos Angeles, California, United StatesRecruiting
Sarah Cannon, SCRI Oncology Partners - Health OneDenver, Colorado, United StatesRecruiting
Sarah Cannon, SCRI Oncology PartnersNashville, Tennessee, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT04678648