Condition: Recurrent Head and Neck Squamous Cell Carcinoma · Recurrent Hypopharyngeal Squamous Cell Carcinoma · Recurrent Laryngeal Squamous Cell Carcinoma · Sponsor: National Cancer Institute (NCI)
This phase II trial studies the effect of pembrolizumab alone compared to the usual approach (chemotherapy \[cisplatin and carboplatin\] plus radiation therapy) after surgery in treating patients with head and neck squamous cell carcinoma that has come back (recurrent) or patients with a second head and neck cancer that is not from metastasis (primary). Radiation therapy uses high energy radiation or protons to kill tumor cells and shrink tumors. Cisplatin is in a class of medications known as platinum-containing compounds. It works by killing, stopping or slowing the growth of cancer cells. Carboplatin is also in a class of medications known as platinum-containing compounds. It works in a way similar to the anticancer drug cisplatin, but may be better tolerated than cisplatin. Carboplatin works by killing, stopping or slowing the growth of cancer cells. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer and may interfere with the ability of tumor cells to grow and spread. Giving pembrolizumab alone after surgery may work better than the usual approach in shrinking recurrent or primary head and neck squamous cell carcinoma.
This description comes directly from the study's public registry record.
Contact details are listed per location below or on the registry record.
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| University of Alabama at Birmingham Cancer Center | Birmingham, Alabama, United States | Active Not Recruiting |
| University of Arkansas for Medical Sciences | Little Rock, Arkansas, United States | Recruiting |
| Kaiser Permanente-Anaheim | Anaheim, California, United States | Recruiting |
| Kaiser Permanente-Bellflower | Bellflower, California, United States | Recruiting |
| UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care | Irvine, California, United States | Recruiting |
| UC San Diego Moores Cancer Center | La Jolla, California, United States | Active Not Recruiting |
| Kaiser Permanente Los Angeles Medical Center | Los Angeles, California, United States | Recruiting |
| Kaiser Permanente-Ontario | Ontario, California, United States | Recruiting |
| UC Irvine Health/Chao Family Comprehensive Cancer Center | Orange, California, United States | Recruiting |
| Sutter Cancer Centers Radiation Oncology Services-Roseville | Roseville, California, United States | Active Not Recruiting |
| Sutter Roseville Medical Center | Roseville, California, United States | Active Not Recruiting |
| California Protons Cancer Therapy Center | San Diego, California, United States | Active Not Recruiting |
+ 166 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT04671667