Condition: Acute Myeloid Leukemia · Sponsor: OHSU Knight Cancer Institute
This phase I trial identifies the best dose and clinical benefit of giving pemigatinib following standard induction chemotherapy in patients with newly diagnosed acute myeloid leukemia. Pemigatinib selectively inhibits FGFR (fibroblast growth factor receptor) activity, a receptor that may contribute to the growth of leukemia cells. The genetic changes responsible for activating the growth of leukemia cells can be unique to each patient and can change during the course of the disease. Chemotherapy drugs, such as cytarabine and daunorubicin work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading.
This description comes directly from the study's public registry record.
OHSU Knight Cancer Institute Clinical Trials Information · 503-494-1080 · trials@ohsu.edu
Always discuss trial participation with your own doctor first.
| OHSU Knight Cancer Institute | Portland, Oregon, United States | Recruiting |
| UT Southwestern/Simmons Cancer Center-Dallas | Dallas, Texas, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT04659616