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Study identifier: NCT04658693 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Functional and Neuroprotective Effects of Restoring Lower Limb Sensation After Diabetic Peripheral Neuropathy

Condition: Lower Extremity Amputee · Diabetic Peripheral Neuropathy  ·  Sponsor: VA Office of Research and Development

PhaseNA
Planned participants15
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this study is to evaluate the effectiveness of providing sensation of the missing limb to individuals with above and below the knee limb loss. The investigators will implanted stimulating electrodes to send small electrical currents to the remaining nerves. These small electrical currents cause the nerves to generate signals that are then transferred to your brain similar to how the information about your foot and lower limb used to be transferred to the brain prior to your limb loss. Additionally, there is the option to have muscle recording electrodes implanted within the muscles of the lower limb with the goal to develop a motor controller that would allow the user to have intuitive control of a robotic prosthetic leg.

This description comes directly from the study's public registry record.

Talk to the study team

Ronald Triolo, PhD  ·  (216) 791-3800  ·  ronald.triolo@va.gov

Aarika Sheehan, DPT  ·  (216) 791-3800  ·  Aarika.Sheehan@va.gov

Always discuss trial participation with your own doctor first.

Locations (1)

Louis Stokes VA Medical Center, Cleveland, OHCleveland, Ohio, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT04658693