Condition: Atrial Fibrillation · Sponsor: Ottawa Hospital Research Institute
Atrial Fibrillation (AF) affects 200,000 Canadians and increases risk of stroke, morbidity and mortality. Having a stroke can affect a patient's ability to speak, eat, walk, work, care for themselves, and interact with others. Not only can it ruin one's life, but it can also be fatal. A stroke occurs when blood flow to the brain is blocked by a clot, depriving brain cells of oxygen. In people with atrial fibrillation, blood flow is sluggish in the top chambers of the heart, and blood clots can form there. When a piece of a clot breaks off, it can travel to the brain and cause a stroke. That's where blood thinners come in. Blood thinners, or anticoagulants, decrease the chances of blood clots forming in the heart, reducing the risk of stroke. Studies show that blood thinners are highly effective at reducing the risk of stroke by up to 95%. The conventional blood thinner is warfarin, taken by mouth. Warfarin requires regular blood tests to make sure a patient getting the correct dose. The patient also may have to avoid certain foods since the medication can interact with them. Newer blood thinners, known as direct-oral anticoagulants (DOACs) are available, which do not require regular blood tests and do not interact with foods. Two of the new blood thinners are called rivaroxaban and apixaban. Like warfarin, they can be taken by mouth, and studies have shown them to be as effective as warfarin. Both rivaroxaban and apixaban have been approved for stroke prevention in AF by He…
This description comes directly from the study's public registry record.
Lana Castellucci, MD, FRCPC · 613-737-8899 · lcastellucci@toh.ca
Erin Thomas · 613-737-8899 · erithomas@toh.ca
Always discuss trial participation with your own doctor first.
| Victoria Cardiac Arrhythmia Trials | Victoria, British Columbia, Canada | Recruiting |
| QEII Health Science Centre | Halifax, Nova Scotia, Canada | Recruiting |
| Kingston General Hospital | Kingston, Ontario, Canada | Recruiting |
| The Ottawa Hospital - General Campus | Ottawa, Ontario, Canada | Recruiting |
| University Ottawa Heart Institute | Ottawa, Ontario, Canada | Recruiting |
| CISSS de l'Outaouais | Gatineau, Quebec, Canada | Recruiting |
| CHU de Quebec - Université Laval | Laval, Quebec, Canada | Not Yet Recruiting |
| Ciusss Nim | Montreal, Quebec, Canada | Recruiting |
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Source record: clinicaltrials.gov/study/NCT04642430