Condition: Renal Pelvis and Ureter Urothelial Carcinoma · Sponsor: National Cancer Institute (NCI)
This phase II/III trial compares the effect of adding durvalumab to chemotherapy versus chemotherapy alone before surgery in treating patients with upper urinary tract cancer. Immunotherapy with monoclonal antibodies, such as durvalumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Chemotherapy drugs, such as methotrexate, vinblastine, doxorubicin, cisplatin, and gemcitabine work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Durvalumab in combination with chemotherapy before surgery may enhance the shrinking of the tumor compared to chemotherapy alone.
This description comes directly from the study's public registry record.
Contact details are listed per location below or on the registry record.
Always discuss trial participation with your own doctor first.
| Kingman Regional Medical Center | Kingman, Arizona, United States | Recruiting |
| Mercy Hospital Fort Smith | Fort Smith, Arkansas, United States | Suspended |
| University of Arkansas for Medical Sciences | Little Rock, Arkansas, United States | Active Not Recruiting |
| Sutter Auburn Faith Hospital | Auburn, California, United States | Active Not Recruiting |
| Alta Bates Summit Medical Center-Herrick Campus | Berkeley, California, United States | Active Not Recruiting |
| City of Hope Comprehensive Cancer Center | Duarte, California, United States | Recruiting |
| Palo Alto Medical Foundation-Fremont | Fremont, California, United States | Active Not Recruiting |
| UC San Diego Moores Cancer Center | La Jolla, California, United States | Recruiting |
| Memorial Medical Center | Modesto, California, United States | Active Not Recruiting |
| Palo Alto Medical Foundation-Camino Division | Mountain View, California, United States | Active Not Recruiting |
| Palo Alto Medical Foundation Health Care | Palo Alto, California, United States | Active Not Recruiting |
| Stanford Cancer Institute Palo Alto | Palo Alto, California, United States | Recruiting |
+ 246 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT04628767