Condition: Desmoplastic Small Round Cell Tumor · Osteosarcoma · Recurrent Desmoplastic Small Round Cell Tumor · Sponsor: National Cancer Institute (NCI)
This phase I/II trial studies the effects of trastuzumab deruxtecan (DS-8201a) in treating patients with osteosarcoma, Wilms tumor (WT) or desmoplastic small round cell tumor (DSRCT) that is newly diagnosed or has come back after a period of improvement (recurrent) or that has not responded to previous treatment (refractory). Trastuzumab deruxtecan is in a class of medications called antibody-drug conjugates. It is composed of a monoclonal antibody, called trastuzumab, linked to a chemotherapy drug, called deruxtecan. Trastuzumab attaches to HER2 positive tumor cells in a targeted way and delivers deruxtecan to kill them.
This description comes directly from the study's public registry record.
Contact details are listed per location below or on the registry record.
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| Children's Hospital of Alabama | Birmingham, Alabama, United States | Suspended |
| Children's Hospital Los Angeles | Los Angeles, California, United States | Suspended |
| Children's Hospital of Orange County | Orange, California, United States | Suspended |
| Lucile Packard Children's Hospital Stanford University | Palo Alto, California, United States | Suspended |
| UCSF Medical Center-Mission Bay | San Francisco, California, United States | Suspended |
| Children's Hospital Colorado | Aurora, Colorado, United States | Suspended |
| Children's National Medical Center | Washington D.C., District of Columbia, United States | Suspended |
| Johns Hopkins All Children's Hospital | St. Petersburg, Florida, United States | Suspended |
| Children's Healthcare of Atlanta - Arthur M Blank Hospital | Atlanta, Georgia, United States | Recruiting |
| Lurie Children's Hospital-Chicago | Chicago, Illinois, United States | Suspended |
| Riley Hospital for Children | Indianapolis, Indiana, United States | Suspended |
| Johns Hopkins University/Sidney Kimmel Cancer Center | Baltimore, Maryland, United States | Recruiting |
+ 16 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT04616560