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Study identifier: NCT04613921 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Liver Transplantation in Patients With CirrHosis and Severe Acute-on-Chronic Liver Failure: iNdications and outComEs

Condition: Liver Diseases · Liver Cirrhosis · Acute-On-Chronic Liver Failure  ·  Sponsor: European Foundation for Study of Chronic Liver Failure

PhaseN/A
Planned participants3000
Who can joinAll sexes, 18 Years to 80 Years
Healthy volunteersNo

About this study

Management of ACLF is mainly supportive. The poor outcomes lead physicians to consider liver transplantation as an option, even if controversial. In sicker recipients, LT results in immediate survival, but poor medium-term survival rates in some studies. The scarcity of deceased donors obliges to maximize LT success. Alternative strategies, as living-donor LT, should be explored. LDLT has impressive results in Eastern centers, but it is restrained in Western countries, due to potential life-threatening complications in the donor.

This description comes directly from the study's public registry record.

Talk to the study team

Anna Bosch  ·  34 93 227 1400  ·  anna.bosch@efclif.com

Always discuss trial participation with your own doctor first.

Locations (106)

Cedars-Sinai Comprehensive Transplant CenterLos Angeles, California, United StatesRecruiting
University of ColoradoAurora, Colorado, United StatesRecruiting
Tampa General HospitalTampa, Florida, United StatesNot Yet Recruiting
Piedmont HealthcareAtlanta, Georgia, United StatesRecruiting
Northwestern Memorial HospitalChicago, Illinois, United StatesNot Yet Recruiting
The University of Chicago MedicineChicago, Illinois, United StatesRecruiting
University of Maryland School of MedicineBaltimore, Maryland, United StatesRecruiting
Weill Cornell MedicineNew York, New York, United StatesRecruiting
Icahn School of Medicine at Mount SinaiNew York, New York, United StatesRecruiting
Montefiore Medical CenterNew York, New York, United StatesNot Yet Recruiting
University of CincinnatiCincinnati, Ohio, United StatesSuspended
Cleveland ClinicCleveland, Ohio, United StatesRecruiting

+ 94 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT04613921