Condition: Advanced Non-Small Cell Lung Cancer · Metastatic Non-Small Cell Lung Cancer · Sponsor: Mirati Therapeutics Inc.
The Phase 2 portion of this study evaluates the efficacy and safety of MRTX849 monotherapy and in combination with pembrolizumab in cohorts of patients with advanced NSCLC with KRAS G12C mutation and any PD-L1 TPS and who are candidates for first-line treatment. The Phase 3 portion of the study compares the efficacy of adagrasib in combination with pembrolizumab versus pembrolizumab in patients with unresectable, locally advanced or metastatic squamous or nonsquamous NSCLC with KRAS G12C mutation and PD-L1 TPS \>=50% and who are candidates for first line treatment.
This description comes directly from the study's public registry record.
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| Local Institution - 007-556-A | Goodyear, Arizona, United States | Not Yet Recruiting |
| USOR - Arizona Oncology - Prescott Valley | Prescott Valley, Arizona, United States | Recruiting |
| Local Institution - 007-568-A | Safford, Arizona, United States | Not Yet Recruiting |
| Local Institution - 007-568-B | Safford, Arizona, United States | Not Yet Recruiting |
| Local Institution - 007-568-C | Safford, Arizona, United States | Not Yet Recruiting |
| Local Institution - 007-568-D | Safford, Arizona, United States | Not Yet Recruiting |
| Local Institution - 007-568-E | Safford, Arizona, United States | Not Yet Recruiting |
| Arizona Clinical Research Center | Tucson, Arizona, United States | Recruiting |
| Highlands Oncology Group - Springdale | Springdale, Arkansas, United States | Recruiting |
| Providence - Saint Joseph Home Health - Anaheim | Anaheim, California, United States | Recruiting |
| The Oncology Institute of Hope and Innovation - Corporate Office | Cerritos, California, United States | Recruiting |
| Local Institution - 007-777 | Fountain Valley, California, United States | Not Yet Recruiting |
+ 758 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT04613596