Condition: Aortic Valve Stenosis · Hypertension,Essential · Heart Failure · Sponsor: Henrik Wiggers
The aim of this study is to investigate the effect of strict blood pressure control versus conventional care in patients with asymptomatic moderate to severe aortic valve stenosis. The study is a randomized (1:1), open label, controlled intervention trial. Hypothesis: 1. Strict BP control for 12 months reduces the progression of LV remodelling compared to conventional treatment. 2. Strict BP control for 2 years reduces the increase in aortic valve calcification and LV remodelling compared to conventional treatment. 3. Strict BP reduction for up to 10 years reduces the need for aortic valve replacement and cardiovascular events compared to conventional care.
This description comes directly from the study's public registry record.
Henrik Wiggers, MD, PhD · henrikwiggers@dadlnet.dk
Jonas A Povlsen, MD · +452270282 · jonapovl@rm.dk
Always discuss trial participation with your own doctor first.
| Dept. of Cardiology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99 | Aarhus, Denmark | Recruiting |
| Dept. of Cardiology, Herning Hospital | Herning, Denmark | Not Yet Recruiting |
| Dept. of cardiology, Horsens Hospital | Horsens, Denmark | Not Yet Recruiting |
| Dept. of cardiology, Randers Hospital | Randers, Denmark | Not Yet Recruiting |
| Silkeborg Hospital | Silkeborg, Denmark | Not Yet Recruiting |
| Dept. of cardiology, Viborg Hospital | Viborg, Denmark | Not Yet Recruiting |
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Source record: clinicaltrials.gov/study/NCT04613193