Condition: Primary Diffuse Large B-Cell Lymphoma of the Central Nervous System · Sponsor: National Cancer Institute (NCI)
This phase I trial tests the safety, side effects, best dose and effectiveness of lenalidomide when added to nivolumab and the usual drugs (rituximab and methotrexate) in patients with primary central nervous system (CNS) lymphoma. Lenalidomide may stop or slow primary CNS lymphoma by blocking the growth of new blood vessels necessary for tumor growth. Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of cancer cells to grow and spread. Rituximab is a monoclonal antibody that may interfere with the ability of cancer cells to grow and spread. Methotrexate is frequently combined with other chemotherapy agents to improve response. This study may help increase the understanding of lenalidomide and nivolumab use in primary CNS lymphoma treatment. In addition, it may help researchers see whether the control of CNS lymphoma can be extended by using these study drugs as maintenance (prolonged therapy) after control is achieved with the initial chemotherapy regimen (induction).
This description comes directly from the study's public registry record.
Contact details are listed per location below or on the registry record.
Always discuss trial participation with your own doctor first.
| Cedars-Sinai Medical Center | Los Angeles, California, United States | Recruiting |
| UCSF Medical Center-Parnassus | San Francisco, California, United States | Recruiting |
| UM Sylvester Comprehensive Cancer Center at Coral Gables | Coral Gables, Florida, United States | Recruiting |
| UM Sylvester Comprehensive Cancer Center at Deerfield Beach | Deerfield Beach, Florida, United States | Recruiting |
| University of Miami Miller School of Medicine-Sylvester Cancer Center | Miami, Florida, United States | Recruiting |
| UM Sylvester Comprehensive Cancer Center at Kendall | Miami, Florida, United States | Recruiting |
| University of Miami Sylvester Comprehensive Cancer Center at Sole Mia | North Miami, Florida, United States | Recruiting |
| UM Sylvester Comprehensive Cancer Center at Plantation | Plantation, Florida, United States | Recruiting |
| UI Health Care Mission Cancer and Blood - Ankeny Clinic | Ankeny, Iowa, United States | Recruiting |
| Saint Anthony Regional Hospital | Carroll, Iowa, United States | Recruiting |
| UI Health Care Mission Cancer and Blood - West Des Moines Clinic | Clive, Iowa, United States | Recruiting |
| Iowa Methodist Medical Center | Des Moines, Iowa, United States | Recruiting |
+ 43 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT04609046