Condition: PreDiabetes · Diabetes type2 · Intermittent Fasting · Sponsor: University Hospital Tuebingen
Type 2 diabetes (T2D) mellitus is a challenge for health care systems as the numbers increases constantly. In 2014, 422 million people had been living with diabetes worldwide. The absolute numbers of people with prediabetes have also grown substantially over 25 years worldwide. In Germany, about 10% of the population has T2D and another 21 % of the population has prediabetes.Overall, 16% of all deaths in Germany are attributable to type 2 diabetes. Macro- and microvascular complications of diabetes imply a significant threat for the patients and are already present in the prediabetic state. Short term and long term complications, the burden of treatment, and reduced quality of life are major burdens of the disease. Accumulating data indicate that currently recommended therapeutic diet regimens in patients with obesity and diabetes are not sustainable on the long term. Novel concepts are therefore urgently needed. T2D occurs when insulin secretion from pancreatic beta-cells cannot sufficiently be increased to compensate for insulin resistance. Causes of beta-cell dysfunction are heterogeneous. In addition, the most important determinants of diabetes remission are the extend of weight loss and restoration of beta-cell function. In the course of diabetes progression, the inability to recover insulin secretion might identify the state of no return to normal glucose tolerance. It is therefore crucial to improve insulin secretion in treatment and prevention of diabetes. Up to now …
This description comes directly from the study's public registry record.
Andreas Fritsche, MD · +49 7071 29 80590 · andreas.fritsche@med.uni-tuebingen.de
Michael Roden, MD · +49 211 3382 201 · michael.roden@ddz.de
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| Charité Berlin - Department of Endocrinology and Metabolic Diseases | Berlin, Germany | Recruiting |
| Universtiy Hospital Carl Gustav Carus | Dresden, Germany | Recruiting |
| German Diabetes Center | Düsseldorf, Germany | Recruiting |
| Heidelberg University Hospital - Department of Endocrinology and Metabolism | Heidelberg, Germany | Recruiting |
| University Hospital Leipzig - Clinic for Endocrinology and Nephrology | Leipzig, Germany | Recruiting |
| University of Luebeck - Institute of Endocrinology and Diabetes | Lübeck, Germany | Recruiting |
| Technical University of Munich - Else Kroener-Fresenius-Center for Nutritional Medicine | Munich, Germany | Recruiting |
| University Hospital Tuebingen - Institute for Diabetes Research and Metabolic Diseases (IDM) | Tübingen, Germany | Recruiting |
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Source record: clinicaltrials.gov/study/NCT04607096