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Study identifier: NCT04606459 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

COSIMA: COronary SInus Reducer for the Treatment of Refractory Microvascular Angina

Condition: Coronary Microvascular Disease · Refractory Angina  ·  Sponsor: Johannes Gutenberg University Mainz

PhaseNA
Planned participants144
Who can joinAll sexes, 18 Years to 85 Years
Healthy volunteersNo

About this study

Patients with refractory microvascular angina fulfilling the predefined inclusion and exclusion criteria will be enrolled in this randomized trial. The primary objective is to investigate whether the proportion of patients reporting an improvement in Canadian Cardiovascular Society (CCS) angina class (≥2 classes) is different at six months after implantation of a Coronary Sinus Reducer followed by optimal medical therapy (OMT) compared to OMT alone.

This description comes directly from the study's public registry record.

Talk to the study team

tommaso gori, PI  ·  +496131172829  ·  tommaso.gori@unimedizin-mainz.de

Always discuss trial participation with your own doctor first.

Locations (1)

Center of Cardiology, Cardiology I, university hospital MainzMainz, Rhineland-Palatinate, GermanyRecruiting

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Source record: clinicaltrials.gov/study/NCT04606459