Condition: Gastric Cancer Stage IV · Sponsor: Yonsei University
Pembrolizumab is a potent humanized immunoglobulin G4 (IgG4) monoclonal antibody (mAb) with high specificity of binding to the programmed cell death 1 (PD 1) receptor, thus inhibiting its interaction with programmed cell death ligand 1 (PD-L1) and programmed cell death ligand 2 (PD-L2). Olaparib is a potent PARP inhibitor (PARP1, 2, and 3) that is being developed as a monotherapy as well as for combination with chemotherapy, ionizing radiation, and other anti-cancer agents including novel agents and immunotherapy. Paclitaxel is widely used in breast, lung and gastric cancer with every 3-week or weekly cycle. Various targeted anticancer agents have been investigated with paclitaxel and combination with ramucirumab, a monoclonal anti-VEGFR2 antibody, was approved as a 2nd line treatment.
This description comes directly from the study's public registry record.
Sun Young Rha, MD. Ph.D · 82-2-2228-8053 · rha7655@yuhs.ac
Always discuss trial participation with your own doctor first.
| Severance Hospital | Seoul, South Korea | Recruiting |
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Source record: clinicaltrials.gov/study/NCT04592211