Condition: Overweight and Obesity · Metabolic Syndrome · Sponsor: Pennington Biomedical Research Center
Adipose, or fat, tissue is a plastic organ that retains the ability to expand and store excess calories during positive energy balance in humans. The capacity of subcutaneous (subQ) adipose tissue to expand and remodel is an important determinant of obesity-related health complications, and impaired expansion of subQ fat tissue is thought to contribute to the risk of diseases such as the Metabolic Syndrome (MetS) and type 2 diabetes mellitus (T2D). The objectives of the study are to evaluate the changes and mechanisms of (subQ) adipose tissue expandability that occur as a result of short-term weight gain and to investigate the effects on cardio-metabolic health outcomes. Findings from this study will provide new insight into the dynamics of adipose expansion and remodeling during changes in energy balance and how this may impact future fat tissue function and metabolic health.
This description comes directly from the study's public registry record.
Ursula White, Ph.D. · 225-763-2656 · ursula.white@pbrc.edu
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| Pennington Biomedical Research Center | Baton Rouge, Louisiana, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT04583514