Condition: Bariatric Surgery · Obesity · Reproductive Health · Sponsor: Assistance Publique - Hôpitaux de Paris
The expansion of the obesity epidemic is accompanied with an increase in bariatric procedures, in particular in women of reproductive age. Severe obesity has negative effects on fertility and on in vitro fertilization (IVF) outcomes, and the weight loss induced by the bariatric surgery (BS) is believed to reverse the deleterious impact of overweight and obesity on female fertility. However, research is limited to retrospective cohort studies, small case-series and case-control studies. Weight reduction has been shown to improve fecundity and hormonal state of a subgroup of obese patients with polycystic ovary syndrome (PCOS). In this population, recent studies have demonstrated an increase of naturally conceived pregnancies following bariatric surgery. However, these studies have evaluated only short-term evolution of ovarian function and not all studies demonstrated improvements in fertility outcomes after BS. Clearly, more studies are needed regarding the effect of BS on obesity-related infertility, and long-term outcome of ovarian function has to be assessed. Markers of ovarian reserve, including Follicle Stimulating Hormone (FSH), antral follicle count (AFC), and anti-mullerian hormone (AMH), have been used to counsel patients regarding in their reproductive outcomes. Serum AMH concentrations remain remarkably stable throughout the menstrual cycle, which is a great advantage over other markers of fertility. Various studies have evaluated the association between AMH and b…
This description comes directly from the study's public registry record.
CIANGURA Cécile, MD · 01 42 17 57 71 · cecile.ciangura@aphp.fr
BACHELOT Anne, MD, PhD · 01 42 16 02 26 · anne.bachelot@aphp.fr
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| CHU Angers | Angers, France | Recruiting |
| CHU Clermont Ferrand -Site Gabriel Montpied | Clermont-Ferrand, France | Recruiting |
| AP-HP - Hôpital Louis Mourier | Colombes, France | Recruiting |
| CHU Dijon Bourgogne - Hôpital Le Bocage Sud | Dijon, France | Not Yet Recruiting |
| CHU Grenoble-CSO Grenoble-Arc Alpin | Grenoble, France | Not Yet Recruiting |
| CHRU Lille -Hôpial Claude Huriez | Lille, France | Not Yet Recruiting |
| HCL - Hôpital Lyon -Sud | Lyon, France | Not Yet Recruiting |
| AP-HM - Hôpital Nord | Marseille, France | Not Yet Recruiting |
| CHU Montpellier Hôpital Lapeyronie | Montpellier, France | Not Yet Recruiting |
| CHU Nantes - Hôpital Nord Laennec | Nantes, France | Not Yet Recruiting |
| AP-HP - Groupe Hospitalier Pitié Salpêtrière | Paris, France | Recruiting |
| AP-HP - Groupe Hospitalier Pitié Salpêtrière | Paris, France | Recruiting |
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Source record: clinicaltrials.gov/study/NCT04583150