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Study identifier: NCT04582903 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Send-In Sample Collection for Comprehensive Analyses of Innate and Adaptive Immune Responses During Acute COVID-19 and Convalescence

Condition: COVID-19 Infection  ·  Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

PhaseN/A
Planned participants5000
Who can joinAll sexes, 1 Day to 99 Years
Healthy volunteersYes

About this study

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19). The global outbreak of COVID-19 is a major public health problem. COVID-19 causes a wide range of symptoms. These symptoms range from mild breathing problems to life-threatening problems or death. Some people have no symptoms. This study aims to learn how acute and late immune responses to COVID-19 lead to different outcomes. The immune system is the body s defense against germs, including viruses, that invade the body. Objective: To characterize the immune responses during and after SARS-CoV-2 infection and determine if there is any relationship to clinical course and outcome. Eligibility: People ages 0 99 who have confirmed or suspected SARS-CoV-2 infection, people who are not infected despite heavy exposure, and relatives of enrolled participants. Design: This is a sample collection protocol to receive send-in biological specimens for exploratory studies, including gene testing. Participants will not be seen at the NIH for study visits. Study staff will talk with participants health care providers to screen them for the study. Participants enrolled into the protocol will send samples and clinical information at least once and more often if the participant has COVID-19. All participants will provide blood samples and possibly stool. We may also ask for left over specimens from any medical procedures completed as part of medical care. The study staff w…

This description comes directly from the study's public registry record.

Talk to the study team

Margaret A Abaandou  ·  (301) 332-4870  ·  margaret.abaandou@nih.gov

Helen C Su, M.D.  ·  (301) 451-8783  ·  hsu@mail.nih.gov

Always discuss trial participation with your own doctor first.

Locations (1)

Niaid/LcimRockville, Maryland, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT04582903