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Study identifier: NCT04575935 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Minimally Invasive Surgery After Neoadjuvant Chemotherapy for the Treatment of Stage IIIC-IV Ovarian, Primary Peritoneal, or Fallopian Tube Cancer, LANCE Trial

Condition: Advanced Ovarian Carcinoma · Fallopian Tube Clear Cell Adenocarcinoma · Fallopian Tube Endometrioid Tumor  ·  Sponsor: M.D. Anderson Cancer Center

PhasePhase 3
Planned participants580
Who can joinFemale, 18 Years to no upper limit
Healthy volunteersNo

About this study

This phase III trial compares minimally invasive surgery (MIS) to laparotomy in treating patients with stage IIIC-IV ovarian, primary peritoneal, or fallopian tube cancer who are receiving chemotherapy before and after surgery (neoadjuvant chemotherapy). MIS is a surgical procedure that uses small incision(s) and is intended to produce minimal blood loss and pain for the patient. Laparotomy is a surgical procedure which allows the doctors to remove some or all of the tumor and check if the disease has spread to other organs in the body. MIS may work the same or better than standard laparotomy after chemotherapy in prolonging the return of the disease and/or improving quality of life after surgery.

This description comes directly from the study's public registry record.

Talk to the study team

Jose A. Rauh-Hain, MD, MPH  ·  713-794-1759  ·  jarauh@mdanderson.org

Always discuss trial participation with your own doctor first.

Locations (19)

University of Miami Miller School of Medicine-Sylvester Cancer CenterMiami, Florida, United StatesRecruiting
Cleveland Clinic Foundation - FloridaWeston, Florida, United StatesRecruiting
Massachusetts General HospitalBoston, Massachusetts, United StatesRecruiting
Dana Farber Cancer InstituteBoston, Massachusetts, United StatesRecruiting
NYU Langone HealthMineola, New York, United StatesRecruiting
Columbia University Medical CenterNew York, New York, United StatesRecruiting
DukeDurham, North Carolina, United StatesRecruiting
Cleveland ClinicCleveland, Ohio, United StatesRecruiting
St. Luke's University Health NetworkBethlehem, Pennsylvania, United StatesRecruiting
Lyndon Baines Johnson GeneralHouston, Texas, United StatesRecruiting
Houston MethodistHouston, Texas, United StatesRecruiting
M D Anderson Cancer CenterHouston, Texas, United StatesRecruiting

+ 7 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT04575935