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Study identifier: NCT04573140 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Study of RNA-lipid Particle (RNA-LP) Vaccines for Newly Diagnosed Pediatric High-Grade Gliomas (pHGG) and Adult Glioblastoma (GBM)

Condition: Adult Glioblastoma · High Grade Glioma · WHO Grade III or IV Malignant Glioma  ·  Sponsor: University of Florida

PhasePhase 1
Planned participants28
Who can joinAll sexes, 4 Years to no upper limit
Healthy volunteersNo

About this study

The primary objective will be to demonstrate the manufacturing feasibility and safety, and to determine the maximum tolerated dose (MTD) of RNA-LP vaccines in (Stratum 1) adult patients with newly diagnosed GBM (MGMT low level or unmethylated in adults only) and (Stratum 2) in pediatric patients with newly diagnosed HGG (pHGG). Funding Source - FDA OOPD

This description comes directly from the study's public registry record.

Talk to the study team

Marcia Hodik  ·  352-273-5519  ·  wells-BTC@ufl.edu

Always discuss trial participation with your own doctor first.

Locations (2)

Children's National HospitalWashington D.C., District of Columbia, United StatesRecruiting
UF HealthGainesville, Florida, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT04573140