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Study identifier: NCT04572256 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

MOntelukast as a Potential CHondroprotective Treatment Following Anterior Cruciate Ligament Reconstruction (MOCHA Trial)

Condition: ACL Injury · Meniscus Tear · Post-traumatic Osteoarthritis  ·  Sponsor: Austin V Stone

PhaseEARLY_Phase 1
Planned participants30
Who can joinAll sexes, 25 Years to 50 Years
Healthy volunteersNo

About this study

This is a multicenter randomized, placebo-controlled trial to assess whether a 6-month course of oral montelukast after ACL reconstruction reduces systemic markers of inflammation and biochemical and imaging biomarkers of cartilage degradation. This study will specifically target older ACL reconstruction patients with concomitant meniscal injuries as this group is at greatest risk of rapid PTOA progression. Patients will randomly be assigned to receive oral montelukast (10 mg) versus placebo daily for 6 months after surgery.

This description comes directly from the study's public registry record.

Talk to the study team

Austin Stone, MD, PhD  ·  859.218.3065  ·  austin.stone@uky.edu

Always discuss trial participation with your own doctor first.

Locations (1)

UK Healthcare at TurflandLexington, Kentucky, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT04572256