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Study identifier: NCT04570085 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Effect of CAFfeine on Cognition in Alzheimer's Disease

Condition: Alzheimer Disease  ·  Sponsor: University Hospital, Lille

PhasePhase 3
Planned participants248
Who can joinAll sexes, 50 Years to no upper limit
Healthy volunteersNo

About this study

Sporadic Alzheimer's disease is a multifactorial illness arising a major medico-economic stakes for our aging societies. There is currently no curative treatment available. Coffee is a complex beverage with psychostimulant properties whose main effective element, caffeine, has a pleiotropic effect on the central nervous system. Caffeine pharmacological properties enable its use like an Alzheimer's disease symptomatic treatment. Its supposed benefits mustn't obscure anxiety and insomnia caffeine effect at large dose, which Alzheimer's patients might be more vulnerable. The main study objective is to evaluate placebo-controlled caffeine efficacy (30 treatments weeks) on cognitive decline in Alzheimer's disease dementia at beginning to moderate stage (MMSE 16-24).

This description comes directly from the study's public registry record.

Talk to the study team

Thibaud LEBOUVIER, MD,PhD  ·  03 20 44 60 21  ·  thibaud.lebouvier@chru-lille.fr

Always discuss trial participation with your own doctor first.

Locations (17)

CHU AmiensAmiens, FranceNot Yet Recruiting
CH ArrasArras, FranceNot Yet Recruiting
CH BeauvaisBeauvais, FranceNot Yet Recruiting
CH BéthuneBéthune, FranceNot Yet Recruiting
CHU CaenCaen, FranceNot Yet Recruiting
CH CalaisCalais, FranceNot Yet Recruiting
CH DunkerqueDunkirk, FranceNot Yet Recruiting
CH Le QuesnoyLe Quesnoy, FranceNot Yet Recruiting
CH LensLens, FranceNot Yet Recruiting
Hôpital Roger SalengroLille, FranceRecruiting
CHU Lille consultation mémoire Les BâteliersLille, FranceNot Yet Recruiting
CH RoubaixRoubaix, FranceNot Yet Recruiting

+ 5 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT04570085