Condition: Plasma Cell Myeloma · RISS Stage I Plasma Cell Myeloma · RISS Stage II Plasma Cell Myeloma · Sponsor: ECOG-ACRIN Cancer Research Group
This phase III trial compares the combination of four drugs (daratumumab, bortezomib, lenalidomide and dexamethasone) to the use of a three drug combination (daratumumab, lenalidomide and dexamethasone). Bortezomib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Chemotherapy drugs, such as lenalidomide, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Daratumumab is a monoclonal antibody that may interfere with the ability of cancer cells to grow and spread. Anti-inflammatory drugs, such as dexamethasone lower the body's immune response and are used with other drugs in the treatment of some types of cancer. Adding bortezomib to daratumumab, lenalidomide, and dexamethasone may be more effective in shrinking the cancer or preventing it from returning, compared to continuing on daratumumab, lenalidomide, and dexamethasone.
This description comes directly from the study's public registry record.
Contact details are listed per location below or on the registry record.
Always discuss trial participation with your own doctor first.
| Anchorage Associates in Radiation Medicine | Anchorage, Alaska, United States | Suspended |
| Anchorage Radiation Therapy Center | Anchorage, Alaska, United States | Suspended |
| Alaska Breast Care and Surgery LLC | Anchorage, Alaska, United States | Suspended |
| Alaska Oncology and Hematology LLC | Anchorage, Alaska, United States | Suspended |
| Alaska Women's Cancer Care | Anchorage, Alaska, United States | Suspended |
| Anchorage Oncology Centre | Anchorage, Alaska, United States | Suspended |
| Katmai Oncology Group | Anchorage, Alaska, United States | Suspended |
| Providence Alaska Medical Center | Anchorage, Alaska, United States | Suspended |
| Cancer Center at Saint Joseph's | Phoenix, Arizona, United States | Recruiting |
| University of Arizona Cancer Center-Orange Grove Campus | Tucson, Arizona, United States | Suspended |
| Banner University Medical Center - Tucson | Tucson, Arizona, United States | Suspended |
| University of Arizona Cancer Center-North Campus | Tucson, Arizona, United States | Suspended |
+ 637 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT04566328