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Study identifier: NCT04564989 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Prospective Observational Study to Validate Circulating HPVDNA and Prognostic Genomic Biomarkers in HPV-associated OPSCC

Condition: Oropharyngeal Squamous Cell Carcinoma · Carcinoma, Squamous Cell · Head and Neck Squamous Cell Carcinoma  ·  Sponsor: UNC Lineberger Comprehensive Cancer Center

PhaseN/A
Planned participants220
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The primary goal of this study is to examine whether recurrence of HPV-associated OPSCC can be predicted by two factors: 1) mutations in genes called TRAF3 and CYLD, and 2) measurements of circulating HPV DNA in blood plasma. The study will also investigate whether HPV integration is associated with TRAF3 and CYLD mutations, and whether recurrence prediction improves when looking at HPV integration along with TRAF3 and CYLD mutations.

This description comes directly from the study's public registry record.

Talk to the study team

Lori Stravers  ·  919-966-4432  ·  lori_stravers@med.unc.edu

Wendell Yarbrough, MD  ·  919-843-7091  ·  dell@med.unc.edu

Always discuss trial participation with your own doctor first.

Locations (3)

Mayo ClinicRochester, Minnesota, United StatesActive Not Recruiting
University of North Carolina at Chapel HillChapel Hill, North Carolina, United StatesRecruiting
Trident Medical Center (HCA Healthcare )North Charleston, South Carolina, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT04564989