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Study identifier: NCT04561518 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

ConTTRibute: A Global Observational Study of Patients With Transthyretin (TTR)-Mediated Amyloidosis (ATTR Amyloidosis)

Condition: Transthyretin-Mediated Amyloidosis · ATTR Amyloidosis  ·  Sponsor: Alnylam Pharmaceuticals

PhaseN/A
Planned participants1500
Who can joinAll sexes, N/A to no upper limit
Healthy volunteersNo

About this study

The purpose of this study is to: * Describe epidemiological and clinical characteristics, natural history and real-world clinical management of ATTR amyloidosis patients * Characterize the safety and effectiveness of patisiran and vutrisiran as part of routine clinical practice in the real-world clinical setting * Describe disease emergence/progression in pre-symptomatic carriers of a known disease-causing transthyretin (TTR) variant

This description comes directly from the study's public registry record.

Talk to the study team

Alnylam Clinical Trial Information Line  ·  1-877-ALNYLAM  ·  clinicaltrials@alnylam.com

Alnylam Clinical Trial Information Line  ·  1-877-256-9526  ·  clinicaltrials@alnylam.com

Always discuss trial participation with your own doctor first.

Locations (40)

Clinical Trial SiteLa Jolla, California, United StatesRecruiting
Clinical Trial SiteLos Angeles, California, United StatesRecruiting
Clinical Trial SiteJacksonville, Florida, United StatesRecruiting
Clinical Trial SiteIowa City, Iowa, United StatesRecruiting
Clinical Trial SiteKansas City, Kansas, United StatesRecruiting
Clinical Trial SiteBaltimore, Maryland, United StatesRecruiting
Clinical Trial SiteBoston, Massachusetts, United StatesCompleted
Clinical Trial SiteNew York, New York, United StatesRecruiting
Clinical Trial SiteDurham, North Carolina, United StatesRecruiting
Clinical Trial SiteColumbus, Ohio, United StatesRecruiting
Clinical Trial SitePhiladelphia, Pennsylvania, United StatesRecruiting
Clinical Trial SiteAustin, Texas, United StatesRecruiting

+ 28 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT04561518