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Study identifier: NCT04557891 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Low-Intensity Focused Ultrasound Pulsation (LIFUP) for the Treatment of Generalized Anxiety Disorder (GAD)

Condition: Generalized Anxiety Disorder  ·  Sponsor: University of California, Los Angeles

PhaseNA
Planned participants48
Who can joinAll sexes, 18 Years to 65 Years
Healthy volunteersNo

About this study

There are few treatment options available for patients once they have failed standard psychopharmacological therapy for generalized anxiety disorder. Existing brain stimulation methods such as rTMS fail to target deep brain structures associated with anxiety disorders; structures such as the amygdala. In this double-blind sham-controlled clinical trial, the investigators propose to establish baseline severity of anxiety in 48 patients, then deliver eight treatments over four sessions of focused ultrasound stimulation to the amygdala. Anxiety severity will be assessed using standard psychometric scales after each session, and at follow-ups.

This description comes directly from the study's public registry record.

Talk to the study team

Margaret G Distler, MD,PhD  ·  (310) 794-1553  ·  mdistler@mednet.ucla.edu

Andrew Bishay, BS  ·  4243719869  ·  abishay@mednet.ucla.edu

Always discuss trial participation with your own doctor first.

Locations (3)

University of California, Los AngelesLos Angeles, California, United StatesRecruiting
Massachusetts General HospitalBoston, Massachusetts, United StatesRecruiting
Medical University of South CarolinaCharleston, South Carolina, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT04557891