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Study identifier: NCT04547777 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Phase 1 Trial of D2C7-IT in Combination With 2141-V11 for Recurrent Malignant Glioma

Condition: Glioma, Malignant  ·  Sponsor: Darell Bigner

PhasePhase 1
Planned participants90
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is a phase 1 study of an anti-CD40 monoclonal antibody (2141-V11) in combination with D2C7-IT for patients with recurrent World Health Organization (WHO) grade III or IV malignant glioma at the Preston Robert Tisch Brain Tumor Center (PRTBTC) at Duke.

This description comes directly from the study's public registry record.

Talk to the study team

Annick Desjardins, MD. FRCPC  ·  919-684-5301  ·  dukebrain1@dm.duke.edu

Stevie Threatt  ·  919-684-5301  ·  dukebrain1@dm.duke.edu

Always discuss trial participation with your own doctor first.

Locations (1)

Duke University Medical CenterDurham, North Carolina, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT04547777