Condition: Down Syndrome · Recurrent B Acute Lymphoblastic Leukemia · Sponsor: National Cancer Institute (NCI)
This phase II trial studies the effect of nivolumab in combination with blinatumomab compared to blinatumomab alone in treating patients with B-cell acute lymphoblastic leukemia (B-ALL) that has come back (relapsed). Down syndrome patients with relapsed B-ALL are included in this study. Blinatumomab is an antibody, which is a protein that identifies and targets specific molecules in the body. Blinatumomab searches for and attaches itself to the cancer cell. Once attached, an immune response occurs which may kill the cancer cell. Nivolumab is a medicine that may boost a patient's immune system. Giving nivolumab in combination with blinatumomab may cause the cancer to stop growing for a period of time, and for some patients, it may lessen the symptoms, such as pain, that are caused by the cancer.
This description comes directly from the study's public registry record.
Contact details are listed per location below or on the registry record.
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| Children's Hospital of Alabama | Birmingham, Alabama, United States | Recruiting |
| USA Health Strada Patient Care Center | Mobile, Alabama, United States | Recruiting |
| Providence Alaska Medical Center | Anchorage, Alaska, United States | Suspended |
| Kingman Regional Medical Center | Kingman, Arizona, United States | Suspended |
| Banner Children's at Desert | Mesa, Arizona, United States | Recruiting |
| Phoenix Childrens Hospital | Phoenix, Arizona, United States | Recruiting |
| Banner University Medical Center - Tucson | Tucson, Arizona, United States | Recruiting |
| Arkansas Children's Hospital | Little Rock, Arkansas, United States | Recruiting |
| Kaiser Permanente-Anaheim | Anaheim, California, United States | Recruiting |
| PCR Oncology | Arroyo Grande, California, United States | Suspended |
| Kaiser Permanente-Bellflower | Bellflower, California, United States | Suspended |
| Kaiser Permanente Downey Medical Center | Downey, California, United States | Recruiting |
+ 213 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT04546399