Condition: Pancreatic Cancer · Adenocarcinoma of the Pancreas · Adenocarcinoma · Sponsor: Gulam Manji
The purpose of this study is to determine if combination treatment with cemiplimab, motixafortide, gemcitabine, and nab-paclitaxel is effective in decreasing the size of the tumor(s), if it will prolong life in patients, and if it's safe. The treatment consists of standard chemotherapy (gemcitabine and nab-paclitaxel) which is FDA approved and is standard treatment for patients with pancreatic adenocarcinoma. Participants will receive immunotherapy (cemiplimab) which activates the body's immune system to attack cancer cells. Cemiplimab is FDA approved for treatment of skin cancer but not for pancreas cancer. Participants will also receive Motixafortide, a new medication which has shown in the laboratory to help immunotherapy work better. Motixafortide has been tested together with immunotherapy (Pembrolizumab), and chemotherapy (5-Fluorouracil and liposomal Irinotecan) and was deemed safe to test additional patients. Motixafortide has not been tested with the specific immunotherapy (Cemiplimab) and chemotherapy (gemcitabine and nab-paclitaxel) which participants will receive and is being tested in this clinical trial.
This description comes directly from the study's public registry record.
Research Nurse Navigator · 212-342-5162 · cancerclinicaltrials@cumc.columbia.edu
Gulam Manji, MD, PhD
Always discuss trial participation with your own doctor first.
| Columbia University Irving Medical Center | New York, New York, United States | Recruiting |
| Brown University | Providence, Rhode Island, United States | Recruiting |
| Medical College of Wisconsin, Wisconsin Diagnostic Labratories | Milwaukee, Wisconsin, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT04543071