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Study identifier: NCT04541654 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Li-Fraumeni & TP53 (LiFT UP): Understanding and Progress

Condition: Li-Fraumeni Syndrome · TP53 Gene Mutation · Hereditary Cancer Syndrome  ·  Sponsor: Dana-Farber Cancer Institute

PhaseN/A
Planned participants1500
Who can joinAll sexes, N/A to no upper limit
Healthy volunteersNo

About this study

The purpose of this research study is to learn more about variants in the TP53 gene both associated with Li-Fraumeni Syndrome (LFS), a hereditary cancer risk condition, and TP53 variants found in the blood for other reasons (e.g. ACE/CHIP and mosaicism).

This description comes directly from the study's public registry record.

Talk to the study team

Judy E Garber, MD, MPH  ·  617-632-5770  ·  jegarber@partners.org

Sophie Cahill, BS  ·  617-632-4795  ·  Sophie_Cahill@DFCI.HARVARD.edu

Always discuss trial participation with your own doctor first.

Locations (3)

Boston Children's HospitalBoston, Massachusetts, United StatesRecruiting
Brigham and Women's HospitalBoston, Massachusetts, United StatesRecruiting
Judy E. GarberBoston, Massachusetts, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT04541654