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Study identifier: NCT04538053 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

BonE and Joint Infections - Simplifying Treatment in Children Trial

Condition: Bone Infection · Septic Arthritis · Bone and Joint Infection  ·  Sponsor: Murdoch Childrens Research Institute

PhasePhase 4
Planned participants285
Who can joinAll sexes, 1 Year to 18 Years
Healthy volunteersNo

About this study

This is a multi- centre trial of children with bone and joint infections (BJIs) at eight major paediatric hospitals in Australia and New Zealand. The primary objective is to establish if in children with acute, uncomplicated BJIs, entirely oral antibiotic treatment is not inferior to initial intravenous (IV) treatment for 1 to 7 days followed by an oral antibiotic course in achieving full recovery 3 months after presentation. Children will be randomly allocated to the 'entirely oral antibiotic' group or the 'standard treatment' group.

This description comes directly from the study's public registry record.

Talk to the study team

Alison Boast, MD  ·  +61393455522  ·  alison.boast@gmail.com

Amanda Gwee, PhD  ·  +61393455522  ·  amanda.gwee@rch.org.au

Always discuss trial participation with your own doctor first.

Locations (10)

Nepean HospitalKingswood, New South Wales, AustraliaRecruiting
John Hunter Children's HospitalNew Lambton Heights, New South Wales, AustraliaRecruiting
Sydney Children's Hospital NetworkSydney, New South Wales, AustraliaRecruiting
The Children's Hospital at WestmeadSydney, New South Wales, AustraliaActive Not Recruiting
Royal Darwin HospitalDarwin, Northern Territory, AustraliaRecruiting
Queensland Children's HospitalBrisbane, Queensland, AustraliaRecruiting
Women's and Children's HospitalAdelaide, South Australia, AustraliaRecruiting
The Royal Children's HospitalMelbourne, Victoria, AustraliaRecruiting
Perth Children's HospitalPerth, Western Australia, AustraliaRecruiting
Christchurch HospitalChristchurch, New ZealandRecruiting

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Source record: clinicaltrials.gov/study/NCT04538053