Condition: Acute Respiratory Distress Syndrome · Sponsor: Sanatorio Anchorena San Martin
Spontaneous breathing during the transition from controlled to assisted ventilation in ARDS may be harmful, as high respiratory drive can generate large transpulmonary pressure swings and worsen lung injury. Higher PEEP may mitigate this by reducing inspiratory effort and lung stress, but patient response is variable and difficult to predict. While improved lung compliance appears to mediate the protective effects of PEEP, its bedside assessment is complex. Preclinical data suggest that changes in compliance are inversely reflected by changes in respiratory rate, but this relationship and its clinical utility in ARDS patients remain unclear.
This description comes directly from the study's public registry record.
Joaquin Pérez, PT · +542245505907 · licjoaquinperez@hotmail.com
Javier H Dorado, PT · +54 1141644262 · javierhdorado@gmail.com
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| Sanatorio Anchorena de San Martin | San Martín, Buenos Aires, Argentina | Recruiting |
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Source record: clinicaltrials.gov/study/NCT04524091