Condition: Frailty · Frailty Syndrome · Frail Elderly Syndrome · Sponsor: The Opole University of Technology
Frailty syndrome (i.e. frailty) is a geriatric syndrome which relies on the reduction of multisystem reserve capacity. Frail people have a lower potential to respond to external stressors and various life incidents as well as they present a weak prognosis particularly in cardiovascular diseases. Yet, frailty is not only a set of physical deficits, but it also concerns psychological and social dimensions of human functioning. Hence, an approach to frailty should be multidimensional because such a concept more adequately reflects a functional degradation in the elderly. Frailty is usually associated with the impaired condition of circulatory system, and therefore, an identification of subclinical cardiovascular abnormalities is paramount in the frailty prevention and treatment. Another potential mechanism which may predispose to frailty is a dysfunction of the autonomic nervous system. This system plays a crucial role in the response to internal or external stressors such as diseases and activities of daily living. An impairment of the autonomic nervous system function may maintain or accelerate the frailty process. In this scientific project, a comprehensive echocardiography will investigate cardiac function with a particular attention to features which typically change with age, like flow parameters and chambers sizes. The activity of the autonomic nervous system will be explored with the analysis of heart rate, blood pressure and respiratory signals. The study participants …
This description comes directly from the study's public registry record.
Jerzy Sacha, MD, PhD · +48 600 273 616 · j.sacha@po.edu.pl
Zbigniew Borysiuk, PhD · +48 77 449 82 50 · z.borysiuk@po.edu.pl
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| Faculty of Physical Education and Physiotherapy, Opole University of Technology | Opole, Poland | Recruiting |
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Source record: clinicaltrials.gov/study/NCT04518423