Condition: Sepsis · Septic Shock · Sponsor: Rennes University Hospital
Immunonutrition in intensive care has not yet demonstrated a beneficial effect on organ failure, the acquisition of nosocomial infections, or mortality. It did not correct for acquired immunosuppression in intensive care patients. Despite numerous methodological problems (use of several pharmaconutrients, very heterogeneous set of patients) and the absence of clinical data, deleterious effects have been attributed to immunonutrition in intensive care, in particular in septic patients and patients in intensive care . Arginine (ARG) is a semi-essential amino acid involved in many immunological mechanisms. It is synthesized in sufficient quantity under normal conditions but quickly becomes insufficient under catabolic conditions such as in severe sepsis. Arginine is not only the precursor of nitrogen monoxide (NO) but also an essential substrate for numerous enzymatic reactions which participate in the maintenance of immune homeostasis, in particular T lymphocyte function. Depletion of the cellular medium in arginine will induce an abnormality in the metabolism of immune cells responsible for a dysfunction of these cells (lymphopenia linked to early apoptosis) and thus expose patients to organ failure and nosocomial infections. It has been found that hypoargininemia in intensive care patients is associated with the persistence of organ dysfunction (SOFA score), the occurrence of nosocomial infections and mortality. Also, it has been demonstrated that in these patients, enteral …
This description comes directly from the study's public registry record.
Mathieu Lesouhaitier, MD · 0033299284321 · mathieu.lesouhaitier@chu-rennes.fr
Jean-Marc Tadié, MD · 0033299284321 · jean-marc.tadie@chu-rennes.fr
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| Rennes University Hospital - Medical ICU | Rennes, Brittany Region, France | Recruiting |
| Rennes University Hospital - Surgical ICU | Rennes, Brittany Region, France | Terminated |
| Besançon University Hospital | Besançon, France | Recruiting |
| Le Mans Hospital | Le Mans, France | Recruiting |
| Tours University Hospital | Tours, France | Recruiting |
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Source record: clinicaltrials.gov/study/NCT04513288