Condition: Metastatic Clear Cell Renal Cell Carcinoma · Metastatic Renal Cell Carcinoma · Stage IV Renal Cell Cancer AJCC v8 · Sponsor: SWOG Cancer Research Network
This phase III trial compares the effect of adding surgery to a standard of care immunotherapy-based drug combination versus a standard of care immunotherapy-based drug combination alone in treating patients with kidney cancer that has spread to other places in the body (metastatic). Immunotherapy with monoclonal antibodies, such as nivolumab, ipilimumab, pembrolizumab, and avelumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Axitinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Surgery to remove the kidney, called a nephrectomy, is also considered standard of care; however, doctors who treat kidney cancer do not agree on its benefits. It is not yet known if the addition of surgery to an immunotherapy-based drug combination works better than an immunotherapy-based drug combination alone in treating patients with kidney cancer.
This description comes directly from the study's public registry record.
Megan Keim, MS · 210-614-8808 · mkeim@swog.org
Dana Sparks, MAT · 210-614-8808 · dsparks@swog.org
Always discuss trial participation with your own doctor first.
| University of Alabama at Birmingham Cancer Center | Birmingham, Alabama, United States | Recruiting |
| Banner MD Anderson Cancer Center | Gilbert, Arizona, United States | Recruiting |
| Kingman Regional Medical Center | Kingman, Arizona, United States | Recruiting |
| Banner University Medical Center - Tucson | Tucson, Arizona, United States | Recruiting |
| University of Arizona Cancer Center-North Campus | Tucson, Arizona, United States | Recruiting |
| Mercy Hospital Fort Smith | Fort Smith, Arkansas, United States | Recruiting |
| PCR Oncology | Arroyo Grande, California, United States | Recruiting |
| Sutter Auburn Faith Hospital | Auburn, California, United States | Recruiting |
| Sutter Cancer Centers Radiation Oncology Services-Auburn | Auburn, California, United States | Recruiting |
| Alta Bates Summit Medical Center-Herrick Campus | Berkeley, California, United States | Recruiting |
| Keck Medicine of USC Buena Park | Buena Park, California, United States | Recruiting |
| Sutter Cancer Centers Radiation Oncology Services-Cameron Park | Cameron Park, California, United States | Recruiting |
+ 375 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT04510597