Condition: Exudative Macular Degeneration · Wet Age-related Macular Degeneration · Sponsor: University of Iowa
Wet (or neovascular) form of age-related macular degeneration (wAMD) is the most common cause of blindness in the Western world. Currently, anti-vascular endothelial growth factor (VEGF) intravitreal injections (IVI) remain the standard-of-care treatment for wAMD. Previous studies show that about 90% of treated patients lose minimal visual function after 2 years of follow-up. There is still, a subset of 15% patients, incomplete responders, that do not improve and possibly worsen due to the persistence of sub-retinal fluid (with or without intra-retinal fluid) with chronic treatment. The investigators plan to evaluate the effect of oral doxycycline versus placebo on the anatomic and functional outcomes in persistent sub-retinal eye fluid in neovascular wet age-related macular degeneration. This subset are incomplete or non-responders to current anti-VEGF intravitreal therapy.
This description comes directly from the study's public registry record.
Elliott H Sohn, MD · 3193563285 · elliott-sohn@uiowa.edu
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| University of Iowa Hospitals & Clinics Department of Ophthalmology & Visual Sciences | Iowa City, Iowa, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT04504123