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Study identifier: NCT04500899 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Use of Phenylephrine for Assessment of Mitral Regurgitation Severity

Condition: Mitral Regurgitation  ·  Sponsor: Montefiore Medical Center

PhasePhase 1/Phase 2
Planned participants35
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The study proposes to develop a phenylephrine protocol to be used during transesophageal echocardiography, whereby intravenous phenylephrine would be used to increase afterload with the intent to mimic the awake hemodynamic profile and variation that occurs with normal physical activity. The expectation is to see changes in severity of Mitral Regurgitation (MR) grade with increasing afterload, which in turn can provide more accurate quantification of MR severity to assist in clinical decision making.

This description comes directly from the study's public registry record.

Talk to the study team

Mario Garcia, MD  ·  718-920-4172  ·  mariogar@montefiore.org

Waqas Hanif, MD  ·  646-270-1421  ·  whanif@montefiore.org

Always discuss trial participation with your own doctor first.

Locations (1)

Montefiore Medical CenterNew York, New York, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT04500899