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Study identifier: NCT04500847 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Repurposing Nucleoside Reverse Transcriptase Inhibitors for Treatment of AD

Condition: Alzheimer Disease, Early Onset · Mild Cognitive Impairment · Moderate Dementia  ·  Sponsor: Butler Hospital

PhasePhase 1
Planned participants35
Who can joinAll sexes, 50 Years to 85 Years
Healthy volunteersNo

About this study

This is a randomized, double-blind clinical trial of a daily oral dose of 200 mg emtricitabine vs. placebo in 35 participants with biomarker-confirmed MCI or mild to moderate dementia due to Alzheimer's disease. Study duration for each subject participating in the placebo-controlled research study will be approximately 12 months (up to a 3 months Screening Period, Baseline visit (1 month), 6 months of placebo or emtricitabine dosing, and 1 month follow-up). Participants will have up to 2 months to complete all procedures for the month 6 study visit.

This description comes directly from the study's public registry record.

Talk to the study team

Meghan Riddle, MD  ·  (401) 455-6403  ·  MRiddle@butler.org

Joslynn Faustino, PhD  ·  (401) 455-6403  ·  JFaustino@butler.org

Always discuss trial participation with your own doctor first.

Locations (2)

Cedars-Sinai Medical CenterLos Angeles, California, United StatesRecruiting
Memory and Aging Program, Butler HospitalProvidence, Rhode Island, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT04500847