← Eichor
Study identifier: NCT04485559 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Trametinib and Everolimus for Treatment of Pediatric and Young Adult Patients With Recurrent Gliomas (PNOC021)

Condition: Recurrent World Health Organization (WHO) Grade II Glioma · Low-grade Glioma · High Grade Glioma  ·  Sponsor: University of California, San Francisco

PhasePhase 1
Planned participants50
Who can joinAll sexes, 1 Year to 25 Years
Healthy volunteersNo

About this study

This phase I trial studies the side effects and best dose of trametinib and everolimus in treating pediatric and young adult patients with gliomas that have come back (recurrent). Trametinib acts by targeting a protein in cells called MEK and disrupting tumor growth. Everolimus is a drug that may block another pathway in tumor cells that can help tumors grow. Giving trametinib and everolimus may work better to treat low and high grade gliomas compared to trametinib or everolimus alone.

This description comes directly from the study's public registry record.

Talk to the study team

PNOC Operations  ·  415-502-1600  ·  PNOC021@ucsf.edu

Sabine Mueller, MD, PhD, MAS  ·  877-827-3222  ·  cancertrials@ucsf.edu

Always discuss trial participation with your own doctor first.

Locations (17)

University of Alabama at Birmingham, Children's of AlabamaBirmingham, Alabama, United StatesRecruiting
Children's Hospital Los AngelesLos Angeles, California, United StatesRecruiting
University of California, San Diego Rady Children's HospitalSan Diego, California, United StatesRecruiting
University of California, San FranciscoSan Francisco, California, United StatesRecruiting
Children's National Medical CenterWashington D.C., District of Columbia, United StatesRecruiting
University of FloridaGainesville, Florida, United StatesRecruiting
Ann & Robert H. Lurie Children's Hospital of ChicagoChicago, Illinois, United StatesRecruiting
Riley Hospital for ChildrenIndianapolis, Indiana, United StatesRecruiting
John Hopkins UniversityBaltimore, Maryland, United StatesRecruiting
Dana Farber Cancer InstituteBoston, Massachusetts, United StatesWithdrawn
Children's MinnesotaMinneapolis, Minnesota, United StatesRecruiting
Washington University in St. LouisSt Louis, Missouri, United StatesRecruiting

+ 5 more locations — full list on the registry record.

Follow this study

Get one email when the public record changes — results posted, or the study's status changes. Nothing else, ever.

We email about this public record only. Unsubscribe anytime with one click. Never medical advice.

Is this your study? This page was generated automatically from the public registry record. Sponsors can claim it — free — to add branding and verified contact routing. Claim this page →

This page is independently generated by Eichor from the public ClinicalTrials.gov record and re-synced daily. It is not the sponsor's official website unless claimed. Nothing here is medical advice; eligibility is always determined by the study team — talk to your own doctor first.

Source record: clinicaltrials.gov/study/NCT04485559