Condition: Recurrent Mantle Cell Lymphoma · Refractory Mantle Cell Lymphoma · Sponsor: City of Hope Medical Center
This phase II trial investigates the side effects of CD19 chimeric antigen receptor (CAR) T cells and acalabrutinib, and to see how well they work in treating patients with mantle cell lymphoma that has come back (relapsed) or does not respond to treatment (refractory). T cells are infection fighting blood cells that can kill cancer cells. The T cells given in this study will come from the patient and will have a new gene put in them that makes them able to recognize CD19, a protein on the surface of the cancer cells. These CD19-specific T cells may help the body's immune system identify and kill CD19 positive cancer cells. Acalabrutinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Giving CD19 CAR T cells together with acalabrutinib may kill more cancer cells.
This description comes directly from the study's public registry record.
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| City of Hope Comprehensive Cancer Center | Duarte, California, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT04484012