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Study identifier: NCT04469530 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Sirolimus in Combination With Metronomic Chemotherapy in Children With High-Risk Solid Tumors

Condition: Solid Tumor  ·  Sponsor: Emory University

PhasePhase 2
Planned participants55
Who can joinAll sexes, 1 Year to 30 Years
Healthy volunteersNo

About this study

The primary objective of this study is to improve the 2-year progression-free survival in children with high-risk solid tumors who are administered a maintenance regimen with continuous sirolimus administered on a backbone of metronomic chemotherapy following the completion of "standard" therapy, as compared to high-risk solid tumor patients treated with observation alone following completion of "standard" therapy.

This description comes directly from the study's public registry record.

Talk to the study team

Kathryn Sutton, MD  ·  404-785-1651  ·  Kathryn.Sutton@choa.org

Always discuss trial participation with your own doctor first.

Locations (5)

Aflac Cancer & Blood Disorders CentersAtlanta, Georgia, United StatesRecruiting
Children's Healthcare of AtlantaAtlanta, Georgia, United StatesRecruiting
Washington University School of MedicineSt Louis, Missouri, United StatesRecruiting
Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center (UPMC)Pittsburgh, Pennsylvania, United StatesRecruiting
Texas Children's Cancer CenterHouston, Texas, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT04469530