Condition: Carpal Tunnel Syndrome · Hand Injuries and Disorders · Nerve Compression · Sponsor: Emily Krauss
Carpal tunnel syndrome (CTS) is the most common nerve compression syndrome worldwide, causing significant chronic pain, functional impairment, and lowered quality of life for individuals of various backgrounds. CTS is caused by chronic compression of the median nerve in the carpal tunnel of the wrist, causing numbness and pain in the palm, thumb, index, and middle fingers and eventual weakness of the hand. Many different treatments for CTS have been proposed and studied, including but not limited to non-operative treatments such as wrist splinting, steroid injections, and lifestyle modifications as well as operative treatments, such as surgical carpal tunnel release (CTR). To date, very few oral medications have been shown to be effective as conservative treatments for CTS. In this study the investigators will examine whether there is any benefit to using oral N-acetylcysteine (NAC) as an adjunctive treatment for mild to moderate CTS in addition to a standard 8-week trial of night splinting. NAC has been used in humans for various purposes, is extremely safe and has very few side effects, and has been shown to have anti-inflammation properties which may help treat CTS. The investigators will study this by performing a randomized controlled trial, comparing patients receiving oral NAC and standard night splinting to patients receiving an identical placebo and standard night splinting. Both patient groups will be assessed using a questionnaire to assess for severity of their CT…
This description comes directly from the study's public registry record.
Emily M Krauss, MD · 902-473-7887 · emilymkrauss@gmail.com
Anna Duncan, MD · anna.duncan@dal.ca
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| Queen Elizabeth II Health Sciences Center, Halifax Infirmary Site | Halifax, Nova Scotia, Canada | Recruiting |
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Source record: clinicaltrials.gov/study/NCT04460521