Condition: Kidney Transplantation for More Than One Year · Patients with a Kidney Transplantation on Cyclosporine · Sponsor: Central Hospital, Nancy, France
Cardiovascular (CV) pathologies are the leading cause of death in kidney transplant patients.Arterial stiffness is a prognostic factor for CV mortality in kidney transplantation. Despite a reduced CV risk in transplant kidney patients in comparison to patients in dialysis, CV mortality among kidney transplant patients is much higher than the general population. After renal transplantation, the cardiac and vascular anomalies observed in chronic end-stage renal disease are partially improved because of restored normal kidney function and withdrawal from dialysis. However, patients are exposed to immunosuppressive drugs, in particular calcineurin inhibitors, which can be associated with vascular toxicity, either directly or by promoting the appearance of hypertension, diabetes, or dyslipidemia.The pathophysiology of arterial stiffness in kidney transplantation is complex and multifactorial. Calcineurin inhibitors are likely to play an important role in the persistence of increased arterial stiffness in transplant patients in whom renal function has been restored. Indeed, the discontinuation of anti-calcineurins in favour of other molecules .is associated with a decrease of arterial stiffness. Preclinical work has shown that the vascular toxicity of cyclosporine is mediated by activation of the mineralocorticoid receptor in smooth muscle cells. The involvement of the mineralocorticoid receptor in the onset of arterial stiffness is also well demonstrated in non-transplanted su…
This description comes directly from the study's public registry record.
Sophie GIRERD, MD-phD · (0) 3 83 15 73 22 · s.girerd@chru-nancy.fr
Nicolas GIRERD, MD-PhD · (0) 3 83 15 73 22 · n.girerd@chru-nancy.fr
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| CHRU de Nancy | Vandœuvre-lès-Nancy, France | Recruiting |
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Source record: clinicaltrials.gov/study/NCT04450953