Condition: Maturation of the Healthy Infant Intestinal Microbiota · Microbial Colonization · Nutrition Disorder, Infant · Sponsor: Insel Gruppe AG, University Hospital Bern
Background: Intestinal microbiota composition is fundamental to human health and undergoes critical changes within the first two years of life. Factors probably influencing the microbiota are the maternal microbiota and the general environment in Switzerland. However, the development of the intestinal microbiota is incompletely understood. Gaining knowledge of the trajectory of microbiota maturation is likely key to the understanding of the pathogenesis of many pathologies in childhood. Aims: The investigators aim for a deep understanding of the maturation of the healthy infant intestinal microbiota regarding composition, diversity and metabolic activities. The investigators aim for identifying parameters affecting microbiota maturation and effects of the microbiota on infant outcome. Methods: The investigators will recruit 250 pregnant mothers who will be followed as mother-baby pairs until 10 years of age. Infants will be followed clinically to determine adequate growth and development as well as pathology including abdominal pain. Epidemiological parameter and infant nutrition will be assessed. The investigators will collect biological samples such as stool, maternal milk, vaginal swaps and skin swaps. Species composition and diversity will be assessed by 16S sequencing. Metagenomic shotgun sequencing and bacterial messenger ribonucleic acid (mRNA) analysis will inform about metabolic potential and metabolic activity of the microbiota. Mass spectrometry will assess the …
This description comes directly from the study's public registry record.
Benjamin Misselwitz, Professor · +41 31 664 04 30 · benjamin.misselwitz@insel.ch
Stephanie Ganal-Vonarburg, Professor · +41 31 632 49 73 · stephanie.ganal@dbmr.unibe.ch
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| University Hospital of Bern - Insel Spital | Bern, Switzerland | Recruiting |
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Source record: clinicaltrials.gov/study/NCT04447742