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Study identifier: NCT04447352 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

HIPEC + FLOT vs. FLOT Alone in Patients With Gastric Cancer and GEJ (PREVENT)

Condition: Gastric Cancer · Gastroesophageal Junction Adenocarcinoma  ·  Sponsor: Krankenhaus Nordwest

PhasePhase 3
Planned participants200
Who can joinAll sexes, 18 Years to 75 Years
Healthy volunteersNo

About this study

This is a multicenter, randomized, controlled, open-label study evaluating efficacy and safety of perioperative FLOT chemotherapy plus intraoperative HIPEC versus FLOT chemotherapy alone in patients with resectable localized and locally advanced diffuse and mixed type adenocarcinoma of the stomach and Type II/III GEJ.

This description comes directly from the study's public registry record.

Talk to the study team

Thorsten O Götze, MD  ·  +4969 7601  ·  goetze.thorsten@khnw.de

Claudia Pauligk, PhD  ·  +4969 7601  ·  pauligk.claudia@khnw.de

Always discuss trial participation with your own doctor first.

Locations (15)

Uniklinik RWTH Aachen, AöR, Medizinische Klinik III, Studienzentrum ViszeralmedizinAachen, GermanyRecruiting
Universitätsklinikum, Klinik und Poliklinik für Viszeral-, Thorax- und GefäßchirurgieDresden, GermanyRecruiting
Institute of Clinical Cancer Research (IKF), UCT - University Cancer Center, Frankfurt, GermanyFrankfurt, GermanyRecruiting
Universitätsklinikum Halle (Saale), Universitätsklinik und Poliklinik für Viszerale, Gefäß- und Endokrine ChirurgieHalle, GermanyRecruiting
Universitätsklinikum Leipzig, Klinik und Poliklinik für Viszeral-, Transplantations-, Thorax- und GefäßchirurgieLeipzig, GermanyRecruiting
Klinikum Ludwigsburg, Klinik für Innere Medizin, Gastroenterologie, Hämato-Onkologie, Pneumologie, Diabetologie und InfektiologieLudwigsburg, GermanyRecruiting
Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Klinik für ChirurgieLübeck, GermanyRecruiting
Universitätsklinikum MagdeburgMagdeburg, GermanyRecruiting
Klinikum rechts der Isar der TU München, Klinik und Poliklinik für Innere Medizin IIIMünchen, GermanyRecruiting
Universitätsklinikum Münster, Klinik für Allgemein-, Viszeral- und TransplantationschirurgieMünster, GermanyRecruiting
Krankenhaus Barmherzige Brüder Regensburg, Klinik für Onkologie und HämatologieRegensburg, GermanyRecruiting
Klinikum Südstadt Rostock, Klinik für Innere Medizin IIIRostock, GermanyRecruiting

+ 3 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT04447352