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Study identifier: NCT04447118 Synced from ClinicalTrials.gov · July 27, 2026
● Completed

Phase 3 Study of Pyrotinib Versus Docetaxel in Patients With Advanced Non-squamous NSCLC Harboring a HER2 Exon 20 Mutation Who Failed Platinum Based Chemotherapy

Condition: Non-squamous NSCLC · HER2 Exon 20 Mutation  ·  Sponsor: Jiangsu HengRui Medicine Co., Ltd.

PhasePhase 3
Planned participants151
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is a randomized, positive-controlled, open-label, international multicenter, Phase 3 clinical study to compare the efficacy and safety of pyrotinib versus docetaxel in patients with advanced non-squamous NSCLC harboring a HER2 exon 20 mutation who failed platinum based chemotherapy.

This description comes directly from the study's public registry record.

Talk to the study team

Contact details are listed per location below or on the registry record.

Always discuss trial participation with your own doctor first.

Locations (102)

University of California - Irvine Medical CenterOrange, California, United States
University of California (UC) Davis Comprehensive Cancer CenterSacramento, California, United States
Innovative Clinical Research InstituteWhittier, California, United States
Florida Cancer Specialists South DivisioFort Myers, Florida, United States
Florida Cancer Specialists North DivisioSt. Petersburg, Florida, United States
University of Kansas Medical Center (KUMC)Kansas City, Kansas, United States
David H. Koch Center for Cancer Care at Memorial Sloan Kettering Cancer CenterNew York, New York, United States
Gabrail Cancer CenterCanton, Ohio, United States
Tennessee OncologyNashville, Tennessee, United States
MD Anderson Cancer CenterHouston, Texas, United States
Summit Cancer Centers - North SpokaneSpokane, Washington, United States
Royal North Shore HospitalSt Leonards, Saint Leonards, Australia

+ 90 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT04447118